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Fax: 0561 7893-1311. This reasoning serves as entrance into our faba bean breeding research, an area that offers numerous challenges and promises due to the bean being a legume (pulse) crop, due to its seed being food and feed in temperate and semi-arid zones, due to it being a field and a garden crop and because winter and spring types exist. Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy, Tampering with springs: phosphorylation of titin affecting the mechanical function of cardiomyocytes, The Impact of cGMP-PKG Pathway Modulation on Titin Phosphorylation and Titin-Based Myocardial Passive Stiffness, Membrane Remodeling by a Bacterial Phospholipid-Methylating Enzyme, Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair, Mechanically Unfolded Titin Immunoglobulin Domains Refold Faster and More Accurately in Presence of Chaperone Alpha-B-Crystallin, A Multi-Tool Mouse Model to Study the Elasticity of Native Titin, Dietary spermidine for lowering high blood pressure, Titin-truncating variants affect heart function in disease cohorts and the general population, Cardioprotection and lifespan extension by the natural polyamine spermidine, Expanding the phenotype of BICD2 mutations toward skeletal muscle involvement, Left Atrial Remodeling and Atrioventricular Coupling in a Canine Model of Early Heart Failure With Preserved Ejection FractionClinical Perspective, Developmental Basis of Cardiac Inherited Diseases470Extracardiac endothelium patterns embryonic coronary arterio-venous connections471DCM-associated RBM20-mutations lead to aberrant splicing of titin and ryanodin receptor 2 in the human myocardium472The impact of missense versus nonsense mutations in arrhythmogenic cardiomyopathy phenotype, Expression and function of dipeptidyl peptidases. Kontakte Fraktion Göttinger Linke . In the original version of this article, the name of one of the authors is not correct. Various professional articles, publications and lectures on general corporate law related issues as well as capital markets subjects. Die Staatsanwaltschaft Göttingen sieht mit Blick auf die Akten über „Linksmotivierte“ keinen Anfangsverdacht bei Mitarbeitern des Göttinger Staatsschutzes. Familial atrial septal defect (ASD) has previously been attributed primarily to mutations in cardiac transcription factors. The prevalance of diastolic dysfunction is higher in females and associates with multiple comorbidities such as hypertension (HT), obesity, hypercholesterolemia (HC), and diabetes mellitus (DM). The pathomechanisms include structural and functional changes affecting, e.g., myofiber metabolism and contractile properties. Only verified researchers can join ResearchGate and send messages to other members. Here, we ha... Loss of cardiac macroautophagy/autophagy impairs heart function, and evidence accumulates that an increased autophagic flux may protect against cardiovascular disease. Professor Dr. Wolfgang Link, Abteilung Zuchtmethodik der Pflanze, Carl-Sprengel-Weg 1, 37075 Göttingen Working Group "Breeding Research Faba Bean" Vicia faba L. is a partially allogamous plant, with an intermediate level of cross- and of self-fertilization, realized by honey and bumble bees. The thin and thick filaments of muscle sarcomeres are interconnected by the giant protein titin, which is a scaffolding filament, signaling platform, and provider of passive tension and elasticity in myocytes. Sehen Sie sich die Profile von Fach- und Führungskräften namens „Wolfgang Link“ auf LinkedIn an. Mesenchymal stromal cells (MSC) have cardiac-protective properties. The spring region of the giant muscle protein titin contains many immunoglobulin-like (Ig) domains, which unfold and refold under low (physiological) stretch forces. He has written four works of comparative literature and psychology of art, now considered standards of their genre. We analyzed 2 independent German families with clinical, geneti... Background: E-Mail: neurologie.sekretariat(at)med.uni … In this study, we discovered a membrane-deforming activity of the phospholipid N -methyltransferase PmtA from the plant-pathogenic bacterium Agrobacterium tumefaciens . Here we show that homozygous deletion (homozygous tm1a, tm1b or tm1d alleles) of Myo18a in mouse is embryonic lethal. This review summarizes recent insight into the mechanisms behind how titin gene mutations cause hereditary cardiomyopathy and how titin prot... Serine/threonine protein phosphatase 5 (PP5) is ubiquitously expressed in eukaryotic cells; however, its function in cardiomyocytes is unknown. We used hetero‐ and homozygous R349P desmin... Background The elasticity of muscle is principally determined by the I-band region of titin, consisting of 40-100 immunoglobulin-like (Ig) domains and Traditional force spectroscopy of titin can study only eight tandem Ig domains at a time, and the dominant However, this use of LVEF in clinical trials has led to oversimplification of the scientific view of a complex syndrome. However, testing these mechanical hypotheses on proteins in their natural environment remains inaccesible to conventional tools. This file is licensed under the Creative Commons Attribution 3.0 Unported license. Recent studies have revealed numerous mutations in the FLNC gene causing familial and sporadic myopathies and cardiomyopathies with marked clinical variability. Here, we describe a mouse model in which Z-disc-anchored TTN is depleted in adult skeletal muscles. 205 likes. For the first time, we report a highly controllable viral expression model based on an iPS-cell line from a healthy human donor. Under basal conditions, PP5 is autoinhibited, but enzymatic activity rises upon binding of specific factors, such as the chaperone Hsp90. The relationship between oxidative stress and cardiac stiffness is thought to involve modifications to the giant muscle protein titin, which in turn can determine the progression of heart disease. The endothelial glycocalyx (eGC), a carbohydrate-rich layer lining the luminal surface of the endothelium, provides a first vasoprotective barrier against vascular leakage in sepsis. A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts.A copy of the license is included in the section entitled GNU Free Documentation License. We show that under mechanical... Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent and intractable form of cardiac decompensation commonly associated with diastolic dysfunction. -Advancing structural and functional maturation of stem cell-derived cardiomyocytes remains a key challenge for applications in disease modelling, drug screening, and heart repair. Universitätsmedizin Göttingen Klinik für Neurologie Robert-Koch-Straße 40 37075 Göttingen . two unstructured segments. E-Mail: dialog@vobakg.de . We combined a geno... Gene expression in human tissue has primarily been studied on the transcriptional level, largely neglecting translational regulation. Protein kinase D (PKD) enzymes play crucial roles in regulating myocardial contraction, hypertrophy, and remodeling. Left ventricular (LV) diastolic dysfunction is among others attributed to cardiomyocyte stiffness. Die Universitätsmedizin Göttingen (UMG) ist Ihr Ansprechpartner für medizinische Versorgung, Lehre und Forschung auf höchstem Niveau. Vicia faba L. is a partially allogamous plant, with an intermediate level of cross- and of self-fertilization, realized by honey and bumble bees. Join ResearchGate to contact this researcher and connect with your scientific community. entropic effect of the massive native titin polypeptide is lost. Universität Göttingen. : You are free: to share – to copy, distribute and transmit the work; to remix – to adapt the work; Under the following conditions: attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. Wolfgang Victor Ruttkowski is a scholar of literature and culture. The Sydney Heart Bank (SHB) is one of the largest human heart tissue banks in existence. Aging is associated with an increased risk of cardiovascular disease and death. Significant progress in the development of echocardiographic equipment and transducers has led to the successful translation of this methodology from humans to rodents, allowing for the scoring of disease severity... Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. Wolfgang. Loslösung von Myosin-Querbrücken immer wiede... Several studies have demonstrated that administration of doxorubicin (DOXO) results in cardiotoxicity, which eventually progresses to dilated cardiomyopathy. Systolic adaptations to these challenges are known but adaptations in diastolic stiffness remain unknown. The giant protein titin forms a continuous filament network in the sarcomeres of striated muscle cells, where it determines passive tension development and modul... Membrane deformation by proteins is a universal phenomenon that has been studied extensively in eukaryotes but much less in prokaryotes. Die Aktin- und Myosinfilamente treten durch Bildung bzw. All rights reserved. The endothelial glycocalyx, a carbohydrate-rich layer lining the endothelial luminal surface, is a first line defense against... Background: Ahmed Sallam, 2014: Detailed genetic approach to improve frost tolerance of German winter faba beans. Friedhof Junkerberg Heinrich-A.-Zachariä-Bogen 12 37077 Göttingen Kontakt: Telefon: 0551/400-5210 Telefax: 0551/400-5222 E-Mail: w.giesse@goettingen.de Supplementary Figure Set for Unger et al., Acta Neuropathol Commun. Whether TTNtv are sufficient to cause DCM or require a second hit for DCM manifestation is an important clinical issue. Band aus Göttingen. Band aus Göttingen. Coxsackievirus B3 (CVB3)-induced myocarditis is associated with severe cardiac inflammation, which may progress to heart failure. Auf LinkedIn können Sie sich das vollständige Profil ansehen und mehr über die Kontakte von Wolfgang Link und Jobs bei ähnlichen Unternehmen erfahren. Cooperation with IAV Hassan II (, Reproductive features and vicine content of faba bean (, Drought tolerance, marker application, faba bean (, Awadallah Abdalla Abdelmula, 1999: Genetic improvement of drought tolerance in faba beans, Hilke M. Riemer, 1999: Nmin nach Ernte: Genotypische Variation in aktiuellem Material von Ackerbohnen (, Jens Christian Vaupel, 1999: Neue CMS-Systeme für die Produktion von Minor x Major-Hybridsorten bei, Memen Surahman, 2001: Detailed genetic analysis of a wide faba bean (, Anja Kramer, 2002: Untersuchungen zum biotechnologisch unterstützten Gentransfer bei der Ackerbohne, Andi Wijaya, 2003: Towards interspecific hybridization in, Mahmoud Mohamed Zeid, 2003: Analysis of genetic diversity based on molecular markers (AFLP) and of heterosis in faba bean (. Accordingly, regulated protein decay is critical to maintain cardiac function. Sorry, you need to be a researcher to join ResearchGate. The last decade has seen enormous progress in our understanding of how titin molecular elasticity is modulated in a dynamic manner to help cardiac sarcomeres adjust to the varying hemodynamic demands on the heart... Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. The established viral model system enables a dose-dependent and highly localized RNA-virus expression in a fully... Filamin C (FLNc) is mainly expressed in striated muscle cells where it localizes to Z-discs, myotendinous junctions and intercalated discs. • The extent of myocardial fibrosis and the degree of isoform-expression and phosphorylation changes in cardiomyocyte titin were unknown in different hemodynamic subgroups of AS, including “paradoxical” low-flow, low-gradient AS with preserved ejection fraction. Reinshof, REPORT, EUFABA N. Metayer '04 V. faba for sust. Voges, 2007: Genetische Analyse von Heterosis im jüngsten Stadium einer Pflanze, als Embryo, am Beispiel der Fababohne (, Franziska Roth, 2010: Evaluierung von Winterackerbohnen als Zwischenfrucht für eine ökologische Biogasproduktion. Aims Mustapha Arbaoui, 2007: Detailed genetic analysis of faba bean, Lamiae Ghaouti, 2007: Comparison of pure line cultivars with synthetic cultivars in local breeding of faba bean (, Susanne Dieckmann geb. We explored whether intravenous (i.v.) 34117 Kassel . The sarcomeric troponin-tropomyosin complex is a critical mediator of excitation-contraction coupling, sarcomeric stability and force generation. 2017 Sep 15;5(1):72. doi: 10.1186/s40478-017-0474-0. nach Vereinbarung. Elevating NAD ⁺ by oral supple... Striated muscle responds to mechanical overload by rapidly up-regulating the expression of the cardiac ankyrin repeat protein, CARP, which then targets the sarcomere by binding to titin N2A in the I-band region. Wolfgang König hat die Professur für Betriebswirtschaftslehre, insbesondere Wirtschaftsinformatik und Informationsmanagement an der Goethe-Universität Frankfurt inne. application of PLacenta-eXpanded (PLX) MSC-like cells (PLX) improves LV diastolic relaxation in streptozotocin (STZ)-induced diabetic mice and i... Myopathies encompass a wide variety of acquired and hereditary disorders. Mitochondrial function is critically dependent on the folding of the mitochondrial inner membrane into cristae; indeed, numerous human diseases are associated with aberrant crista morphologies. The giant muscle protein titin is a major contributor to passive force; however, its role in active force generation is unresolved. Loop is the open research network that increases the discoverability and impact of researchers and their work. With this reproductive behaviour, breeding methods appropriate for faba bean should be general solutions of which the methods for self-fertilizing and cross-fertilizing crops should be just extreme, marginal cases. International space missions with ESA and NASA. Cuvillier Verlag Göttingen. Highlights Daniel Siebrecht-Schöll, 2019: Breeding analysis of eight winter faba bean genotypes for mixed cropping with winter wheat. In the Western countries cardiovascular disease and cancer are the leading causes of death in the ageing population. Stadt Göttingen Breslauer Straße 2 37085 Göttingen. Universität Göttingen. Seif Eldin Gasim, 2003: Winter-hardy faba bean: Applied genetic research on the reproductive mode of the European gene pool. Crucial role of protein kinase G in regulating Ca2(+)/calmodulin-dependent protein kinase-II activity and oxidative stress: The diastolic function modulation via PKG-dependent CaMKII phosphorylation and oxidation. Although several studies in non-mammalian vertebrates have proven that extracardiac endothelial cells also participate in CoE development, the contribution of such cells to mammalian CoE is regarded to be minor and... Elucidating the biological mechanisms behind increased myocardial compliance following acute myocardial stretching and their role in cardiac diastolic (dys)function.

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